反应详情

To a mixture of 5-[4-[6-(8-aminonaphthalen-2-yloxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione (0.5 g) and N,N-dimethylformamide (10 ml) was added 2,6-diisopropylphenyl isocyanate (0.20 g) and the mixture was allowed to stand at room temperature for 5 days. The reaction mixture was partitioned between ethyl acetate and water. The extract was washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and then concentrated. The residue was chromatographed on a silica gel column using ethyl acetate:n-hexane=3/2→3/1 as the eluant. The product was recrystallized from methanol to afford the title compound (0.24 g, mp 164-169° C.).

1. customThe reaction mixture was partitioned between ethyl acetate and water
2. washThe extract was washed with saturated aqueous sodium chloride solution
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated
5. customThe residue was chromatographed on a silica gel column
6. customThe product was recrystallized from methanol