反应详情

A solution of 3-hydroxy-4-nitrophenylacetic acid (4.0 g, prepared according to the procedure described by Meyer et al, J. Med. Chem., 1997, 40, pages 1049-1062) in ethanol (approximately 100 ml) was treated with concentrated hydrochloric acid (5-8 drops) was heated at reflux temperature for 3 hours then evaporated. The residue was dissolved in tert-butyl methylether and the solution was washed with saturated aqueous sodium bicarbonate solution, then with water, then dried, and then evaporated to give the title compound (5.0 g) as a light yellow solid.

1. temperaturewas heated
2. temperatureat reflux temperature for 3 hours
3. customthen evaporated
4. dissolutionThe residue was dissolved in tert-butyl methylether
5. washthe solution was washed with saturated aqueous sodium bicarbonate solution
6. dry with materialwith water, then dried
7. customevaporated