反应详情

4-(2-Amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic acid ethyl ester dihydrochloride (9 g) was dissolved in conc. hydrochloric acid (50 ml), and the mixture was stirred under reflux for 3 hours. After completion of the reaction, insoluble material was filtered off and the solvent was evaporated. The residue was dried under reduced pressure to give the title compound (9.0 g).

1. temperatureunder reflux for 3 hours
2. customAfter completion of the reaction, insoluble material
3. filtrationwas filtered off
4. customthe solvent was evaporated
5. customThe residue was dried under reduced pressure