反应详情

To a solution of 7-(1-tert-butoxycarbonyl-4-ethoxycarbonylpiperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester (165 mg) in chloroform (1.5 ml) was added dropwise trifluoroacetic acid (0.5 ml), and the mixture was stirred at room temperature for 1 hour. The solvent was evaporated and aqueous sodium hydrogencarbonate solution was added to the obtained residue. The mixture was extracted with ethyl acetate and the organic layer was dried over anhydrous sodium sulfate. The solvent was evaporated and the residue was dried under reduced pressure to give the title compound (135 mg).

1. customThe solvent was evaporated
2. additionaqueous sodium hydrogencarbonate solution was added to the obtained residue
3. extractionThe mixture was extracted with ethyl acetate
4. dry with materialthe organic layer was dried over anhydrous sodium sulfate
5. customThe solvent was evaporated
6. customthe residue was dried under reduced pressure