Hydrochloric Acid → HCID 69697711, compound

HRID 412535Notes

Reaction equation

HRID 412535 reaction equation
[ClH:1].Cl.C([O:5][C:6]([C:8]1([CH2:22][O:23][C:24]2[CH:33]=[C:32]3[C:27]([CH2:28][CH2:29][N:30]([C:34](=[NH:36])[NH2:35])[CH2:31]3)=[CH:26][CH:25]=2)[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[C:18]([CH3:20])[N:17]=[C:16]([CH3:21])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])C.Cl>>[ClH:1].[ClH:1].[C:34]([N:30]1[CH2:29][CH2:28][C:27]2[C:32](=[CH:33][C:24]([O:23][CH2:22][C:8]3([C:6]([OH:7])=[O:5])[CH2:9][CH2:10][N:11]([C:14]4[CH:15]=[C:16]([CH3:21])[N:17]=[C:18]([CH3:20])[CH:19]=4)[CH2:12][CH2:13]3)=[CH:25][CH:26]=2)[CH2:31]1)(=[NH:35])[NH2:36]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 10280369HCID 10280369, compound

Product 1

HCID 69697711HCID 69697711, compoundYield 188.7%

Procedure

To 4-(2-amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)-1-(2,6-dimethylpyridin-4-yl)piperidine-4-carboxylic acid ethyl ester dihydrochloride (85 mg) was added 6N hydrochloric acid, and the mixture was stirred under reflux for 3 hours. After completion of the reaction, insoluble material was removed and the solvent was evaporated. The obtained residue was washed with diethyl ether and dried under reduced pressure to give the title compound (76 mg).

Workup

  1. temperatureunder reflux for 3 hours
  2. customAfter completion of the reaction, insoluble material
  3. customwas removed
  4. customthe solvent was evaporated
  5. washThe obtained residue was washed with diethyl ether
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-85ddf57a026b4bc09e3ed3e7cfc4bd4d
Source dataset
uspto-grants-2003_05
Patent number
US06562828B1

Reaction notes

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