反应详情

To a solution of 7-[1-(2-chloropyrimidin-4-yl)-4-ethoxycarbonylpiperidin-4-ylmethoxy]-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester (263 mg) in ethanol(5 ml) were added 7.5% palladium carbon (120 mg) and ammonium formate (200 mg) with ice-cooling, and the mixture was stirred under reflux for 30 min. After completion of the reaction, the solvent was evaporated and water was added to the obtained residue. The mixture was extracted with chloroform and the organic layer was washed with aqueous sodium hydrogencarbonate solution and dried over anhydrous sodium sulfate. The solvent was evaporated and the residue was dried under reduced pressure to give the title compound (270 mg).

1. temperaturecooling
2. temperatureunder reflux for 30 min
3. customAfter completion of the reaction
4. customthe solvent was evaporated
5. additionwater was added to the obtained residue
6. extractionThe mixture was extracted with chloroform
7. washthe organic layer was washed with aqueous sodium hydrogencarbonate solution
8. dry with materialdried over anhydrous sodium sulfate
9. customThe solvent was evaporated
10. customthe residue was dried under reduced pressure