反应详情

4-(4-Nitrophenoxy)piperidine-1-carboxylic acid tert-butyl ester (53.687 g) was hydrogenated using 7.5% palladium carbon (8.05 g) in a mixture of tetrahydrofuran (215 ml) and ethanol (215 ml) at 3 atm over 3 hours. After completion of the reaction, the reaction mixture was filtered through celite and the solvent was evaporated. Hexane was added to the obtained residue, and the obtained solid was collected by filtration and dried under reduced pressure to give the title compound (42.157 g).

1. customAfter completion of the reaction
2. filtrationthe reaction mixture was filtered through celite
3. customthe solvent was evaporated
4. additionHexane was added to the obtained residue
5. filtrationthe obtained solid was collected by filtration
6. customdried under reduced pressure