反应详情

A solution of 4-chloro-3-nitrobenzonitrile (10.13 g) and ethanolamine (3.52 ml) in a mixture of ethanol (150 ml) and tetrahydrofuran (50 ml) was stirred at room temperature for 2 hours. Ethanolamine (3.35 ml) was added and the mixture was stirred at 50° C. for 1 hour. Then, ethanolamine (3.35 ml) was added, and the mixture was stirred at the same temperature for 1 hour. After completion of the reaction, the solvent was evaporated and the obtained solid was washed with isopropanoyl, collected by filtration, and dried under reduced pressure to give the title compound (7.25 g).

1. stirringthe mixture was stirred at 50° C. for 1 hour
2. stirringthe mixture was stirred at the same temperature for 1 hour
3. customAfter completion of the reaction
4. customthe solvent was evaporated
5. washthe obtained solid was washed with isopropanoyl
6. filtrationcollected by filtration
7. customdried under reduced pressure