反应详情

To a solution of 4-hydroxymethylpiperidine-1-carboxylic acid benzyl ester (1.11 g), carbon tetrabromide (1.77 g) in methylene chloride (11 ml) was added triphenylphosphine (1.4 g) with ice-cooling, and the mixture was stirred at room temperature for 5 hours. After completion of the reaction, the solvent was evaporated and the obtained residue was purified by silica gel column chromatography (hexane:acetone=10:1) and dried under reduced pressure to give the title compound (1.25 g).

1. temperaturecooling
2. customAfter completion of the reaction
3. customthe solvent was evaporated
4. customthe obtained residue was purified by silica gel column chromatography (hexane:acetone=10:1)
5. customdried under reduced pressure