Hydrochloric Acid → Ethyl 2-phenylacetimidate hydrochloride

HRID 412569Notes

Reaction equation

HRID 412569 reaction equation
[ClH:1].[CH2:2]([C:9]#[N:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:11]([O:13]CC)[CH3:12]>>[ClH:1].[C:3]1([CH2:2][C:9](=[NH:10])[O:13][CH2:11][CH3:12])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 8794Phenylacetonitrile

Product 1

HCID 12218775Ethyl 2-phenylacetimidate hydrochloride

Procedure

Hydrogen chloride was blown into a solution of benzyl cyanide (5.8 ml) in diethyl ether (10 ml) with ice-cooling, and the mixture was stood at room temperature for 12 hours. After completion of the reaction, the solvent was evaporated. The obtained solid was washed with diethyl ether, collected by filtration and dried under reduced pressure to give the title compound (9.43 g).

Workup

  1. temperaturecooling
  2. customAfter completion of the reaction
  3. customthe solvent was evaporated
  4. washThe obtained solid was washed with diethyl ether
  5. filtrationcollected by filtration
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-6b8feb7a0a8a491db3169430ebfbaed5
Source dataset
uspto-grants-2003_05
Patent number
US06562828B1

Reaction notes

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