反应详情

To a solution of lithium aluminum hydride (3.07 g) in tetrahydrofuran (60 ml) was dropwise added a solution of 8-methoxy-2,3,4,5-tetrahydrobenz[c]azepin-1-one (4.42 g) in 1,4-dioxane (30 ml) with ice-cooling and the mixture was refluxed for 20 hours. After completion of the reaction, 20% aqueous sodium hydroxide solution was added dropwise with ice-cooling, and the mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was filtrated, and the solvent was evaporated and the residue was dried under reduced pressure to give the title compound (4.05 g).

1. temperaturecooling
2. temperaturethe mixture was refluxed for 20 hours
3. additionwas added dropwise with ice-
4. temperaturecooling
5. customAfter completion of the reaction
6. filtrationthe reaction mixture was filtrated
7. customthe solvent was evaporated
8. customthe residue was dried under reduced pressure