Hydrogen Bromide → 2,3,4,5-tetrahydro-1H-2-benzazepin-8-ol hydrobromide

HRID 412595Notes

Reaction equation

HRID 412595 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH2:11][CH2:10][NH:9][CH2:8][C:7]=2[CH:13]=1.[BrH:14]>>[BrH:14].[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH2:11][CH2:10][NH:9][CH2:8][C:7]=2[CH:13]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 154969548-Methoxy-2,3,4,5-tetrahydro-1H-benzo(c)azepine

Product 1

HCID 114479102,3,4,5-tetrahydro-1H-2-benzazepin-8-ol hydrobromide

Procedure

8-Methoxy-2,3,4,5-tetrahydro-1H-benz[c]azepine (3.65 g) was dissolved in 48% aqueous hydrogen bromide solution (36 ml) and the mixture was refluxed for 2 hours. The solvent was evaporated and ethanol and diethyl ether were added to the obtained residue. The mixture was filtrated and dried under reduced pressure to give the title compound (4.56 g).

Workup

  1. temperaturethe mixture was refluxed for 2 hours
  2. customThe solvent was evaporated
  3. additionethanol and diethyl ether were added to the obtained residue
  4. filtrationThe mixture was filtrated
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-949b71e773254f5188db2f623d3f8843
Source dataset
uspto-grants-2003_05
Patent number
US06562828B1

Reaction notes

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