Hydrochloric Acid → HCID 11261097, compound

Participants

Reaction Steps

To 4-(2-amidino-1,2,3,4-tetrahydroisoquinolin-7-ylsulfonylamino)-1-(pyridin-4-yl)piperidine-4-carboxylic acid methyl ester dihydrochloride (415 mg) was added 6N hydrochloric acid (2 ml), and the mixture was stirred under reflux for 4 hours. After completion of the reaction, insoluble material was removed and the solvent was evaporated. Diethyl ether was added and the resultant solid was collected by filtration and dried under reduced pressure to give the title compound (363 mg).

Provenance & Evidence