Hydrochloric Acid → HCID 11261097, compound

HRID 412605Notes

Reaction equation

HRID 412605 reaction equation
[ClH:1].Cl.C[O:4][C:5]([C:7]1([NH:19][S:20]([C:23]2[CH:32]=[C:31]3[C:26]([CH2:27][CH2:28][N:29]([C:33](=[NH:35])[NH2:34])[CH2:30]3)=[CH:25][CH:24]=2)(=[O:22])=[O:21])[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[CH2:9][CH2:8]1)=[O:6].Cl>>[ClH:1].[ClH:1].[C:33]([N:29]1[CH2:28][CH2:27][C:26]2[C:31](=[CH:32][C:23]([S:20]([NH:19][C:7]3([C:5]([OH:6])=[O:4])[CH2:12][CH2:11][N:10]([C:13]4[CH:14]=[CH:15][N:16]=[CH:17][CH:18]=4)[CH2:9][CH2:8]3)(=[O:22])=[O:21])=[CH:24][CH:25]=2)[CH2:30]1)(=[NH:34])[NH2:35]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11398667HCID 11398667, compound

Product 1

HCID 11261097HCID 11261097, compoundYield 179.6%

Procedure

To 4-(2-amidino-1,2,3,4-tetrahydroisoquinolin-7-ylsulfonylamino)-1-(pyridin-4-yl)piperidine-4-carboxylic acid methyl ester dihydrochloride (415 mg) was added 6N hydrochloric acid (2 ml), and the mixture was stirred under reflux for 4 hours. After completion of the reaction, insoluble material was removed and the solvent was evaporated. Diethyl ether was added and the resultant solid was collected by filtration and dried under reduced pressure to give the title compound (363 mg).

Workup

  1. temperatureunder reflux for 4 hours
  2. customAfter completion of the reaction, insoluble material
  3. customwas removed
  4. customthe solvent was evaporated
  5. additionDiethyl ether was added
  6. filtrationthe resultant solid was collected by filtration
  7. customdried under reduced pressure

Sources & evidence

ORD record
ord-25155de1836d4e47b100b4567118fd4f
Source dataset
uspto-grants-2003_05
Patent number
US06562828B1

Reaction notes

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