反应详情

To a solution of 4-benzyloxycarbonylaminomethyl-1-(pyridin-4-yl)piperidine-4-carboxylic acid ethyl ester (331 mg) in chloroform (0.5 ml) was added 25% hydrogen bromide-acetic acid (2 ml), and the mixture was stirred at room temperature for 10 min. After completion of the reaction, hexane, diisopropyl ether and diethyl ether were added and the supernatant was removed. Then, dimethylformamide (1 ml) was added and the resultant solid was collected by filtration, and washed with diethyl ether and dried under reduced pressure to give the title compound (423 mg).

1. additionwere added
2. customthe supernatant was removed
3. additionThen, dimethylformamide (1 ml) was added
4. filtrationthe resultant solid was collected by filtration
5. washwashed with diethyl ether
6. customdried under reduced pressure