1-(Pyridin-4-yl)piperidine-4-carbamic acid benzyl ester → 1-(Pyridin-4-yl)piperidin-4-amine

Participants

Reaction Steps

1-(Pyridin-4-yl)piperidine-4-carbamic acid benzyl ester (9.46 g) was hydrogenated using 7.5% palladium carbon (3.57 g) in ethanol (95 ml) solution at 3 atm over 3 hours. After completion of the reaction, the reaction mixture was filtered through celite, and the solvent was evaporated and the residue was dried under reduced pressure to give the title compound (5.38 g).

Provenance & Evidence