HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 412674Generated: October 26, 2026
Gamma-Aminobutyric Acid → Alendronic Acid
https://huagongshe.com/reaction/412674
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Gamma-Aminobutyric Acid | HCID 119 | — |
| Reactant | Phosphorus trichloride | HCID 24387 | — |
| Reactant | Phosphorous acid | HCID 107909 | — |
| Product | Alendronic Acid | HCID 2088 | — |
Reaction Steps
The mixture of 5 eq. phosphorous acid, 4-aminobutyric acid and morpholine. HCl is melted together until uniform solution is formed. The reaction mixture is cooled to about 70° C. and 2 eq. of PCl3 are carefully added. The mixture is heated for about 5.5 hours before the reaction mixture is hydrolyzed in aqueous acid at about 80° C. and alendronate is isolated from an ethanolic solution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06562974B2 |
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| Source dataset | uspto-grants-2003_05 |
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| ORD ID | ord-b3a0f7fd2bd7403f9357ce99aee0cb71 |
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| Source note | uspto-grants-2003_05 |
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