反应详情

温度

70 °C

The mixture of 5 eq. phosphorous acid, 4-aminobutyric acid and morpholine. HCl is melted together until uniform solution is formed. The reaction mixture is cooled to about 70° C. and 2 eq. of PCl3 are carefully added. The mixture is heated for about 5.5 hours before the reaction mixture is hydrolyzed in aqueous acid at about 80° C. and alendronate is isolated from an ethanolic solution.

1. customis formed
2. temperatureThe mixture is heated for about 5.5 hours before the reaction mixture
3. customis hydrolyzed in aqueous acid at about 80° C.