反应详情

To a dichloromethane (670 μl) solution of 3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methyl-2-(methylthio)-N,N-dipropylpyrazolo[5,1-b][1,3]thiazole-7-amine (31.5 mg, 0.068 mmol) was added 3-chloroperbenzoic acid (23.4 mg, 0.136 mmol), and the mixture was stirred at room temperature for 10 minutes. To the reaction mixture, a saturated aqueous solution of sodium carbonate was added, the mixture was extracted with dichloromethane, and then, the organic layer was dried over anhydrous magnesium sulfate. The mixture was filtered to yield a filtrate, and the solvent in the filtrate was distilled off under reduced pressure. The residue was purified by thin-layer silica gel chromatography (chloroform:methanol=12:1) to obtain 7.3 mg (0.0152 mmol) of the title compound.

1. extractionthe mixture was extracted with dichloromethane
2. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
3. filtrationThe mixture was filtered
4. customto yield a filtrate
5. distillationthe solvent in the filtrate was distilled off under reduced pressure
6. customThe residue was purified by thin-layer silica gel chromatography (chloroform:methanol=12:1)