Hydrogen Bromide → HCID 68656375, compound

HRID 412725Notes

Reaction equation

C([O:8][C:9]([C:11]1[CH:12]=[CH:13][C:14](OCCNC(C2C=CC3N=C(C(C4NC5CCNCC=5N=4)C)N(C)C=3C=2)=O)=[C:15]([CH:19]=1)C(O)=O)=[O:10])C1C=CC=CC=1.[BrH:47]>C(O)(=O)C>[BrH:47].[C:9]([OH:10])(=[O:8])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:19]=1

Participants

Conditions

Temperature: 10 °C

Procedure

A solution comprising 5-benzyloxycarbonyl-2-(2-{3-methyl-2-[1-(4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)ethyl]-3H-benzoimidazol-5-ylcarbonylamino}ethoxy)benzoic acid (0.561 g, 0.90 mmol) in glacial acetic acid (2 mL) was heated under nitrogen in a water bath to 10° C., treated with hydrogen bromide in acetic acid (2 mL of a 30% solution) and allowed to warm to 20° C. and, one hour later, concentrated with a stream of nitrogen. The residue was dissolved in a small quantity of ethanol and the solution was added dropwise to stirring ether to give a pale brown precipitate. The precipitate was isolated by filtration and dried to provide 2-(2-{3-methyl-2-[4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)ethyl]-3H-benzoimidazol-5-ylcarbonylamino}ethoxy)benzoic acid hydrobromide (0.651 g); 1H-NMR (300 MHz, DMSO-d6) d ppm: 9.31 (br s, 2H), 8.63 (m, 1H), 8.24 (s, 1H), 7.79 (d, 1H, J=7.9 Hz), 7.63 (m, 2H), 7.47 (t, 1H, J=7.9 Hz), 7.21 (d, 1H, J=7.9 Hz), 7.00 (t, 1H, J=7.9 Hz), 5.21 (q, 1H, J=6.3 Hz), 4.29 (s, 2H), 4.21 (s, 2H), 3.91 (s, 3H), 3.68 (m, 2H), 3.43 (m, 2H), 2.89 (s, 2H), 1.79 (d, 3H, J=6.3 Hz).

Workup

temperatureto warm to 20° C. and, one hour later
concentrationconcentrated with a stream of nitrogen
dissolutionThe residue was dissolved in a small quantity of ethanol
additionthe solution was added dropwise
customto give a pale brown precipitate
customThe precipitate was isolated by filtration
customdried

Sources & evidence

ORD record: ord-e40b7149911b452dbb417d8651e19caf
Source dataset: uspto-grants-2003_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06562854B2

Reaction notes

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