反应详情

Ethyl isonipecotate (31.44 g, 200 mmol) and triethylamine (50.2 ml, 360 mmol) were dissolved in THF (500 ml), and under ice cooling, to the solution was added dropwise methanesulfonyl chloride (23.2 ml 300 mmol). The mixture was stirred at the same temperature for 1 hour. Under ice cooling, water (200 ml) was added, and the organic layer was distilled off under reduced pressure. The aqueous layer was extracted with ethyl acetate (200 ml, 100 ml×2). The organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate (50 ml×2), 1N-hydrochloric acid (50 ml×3), saturated sodium chloride solution (50 ml), successively, dried over magnesium sulfate and concentrated under reduced pressure. To the concentrate was added diisopropyl ether (100 ml), and the resulting precipitates were collected by filtration. The precipitates were washed with diisopropyl ether (50 ml×3), and dried under reduced pressure to give the titled compound (43.20 g, 184 mmol, 1 Yield 92%) as white crystals.

1. distillationthe organic layer was distilled off under reduced pressure
2. extractionThe aqueous layer was extracted with ethyl acetate (200 ml, 100 ml×2)
3. washThe organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate (50 ml×2), 1N-hydrochloric acid (50 ml×3), saturated sodium chloride solution (50 ml)
4. dry with materialsuccessively, dried over magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. additionTo the concentrate was added diisopropyl ether (100 ml)
7. customthe resulting precipitates
8. filtrationwere collected by filtration
9. washThe precipitates were washed with diisopropyl ether (50 ml×3)
10. customdried under reduced pressure