Tert-butyl 4-hydroxypiperidine-1-carboxylate → 4-(Pyrazin-2-ylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester

HRID 412886Notes

Reaction equation

HRID 412886 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11](O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[SH:15][C:16]1[CH:21]=[N:20][CH:19]=[CH:18][N:17]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([S:15][C:16]2[CH:21]=[N:20][CH:19]=[CH:18][N:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 178527737HCID 178527737, compound

Product 1

HCID 185386084-(Pyrazin-2-ylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester

Procedure

By a similar manner to Reference Example 35, 1-tert-butoxycarbonyl-4-hydroxypiperidine (1.01 g, 5.0 mmol) was reacted with mercaptopyrazine (0.67 g, 6.0 mmol) to give the titled compound as pale yellow oily substance (1.26 g, 85%).

Sources & evidence

ORD record
ord-ea59a934baf8491a861043e0ca5e19af
Source dataset
uspto-grants-2003_05
Patent number
US06562978B1

Reaction notes

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