Tert-butyl 4-hydroxypiperidine-1-carboxylate → 4-(Pyrazin-2-ylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester

Participants

Reaction Steps

By a similar manner to Reference Example 35, 1-tert-butoxycarbonyl-4-hydroxypiperidine (1.01 g, 5.0 mmol) was reacted with mercaptopyrazine (0.67 g, 6.0 mmol) to give the titled compound as pale yellow oily substance (1.26 g, 85%).

Provenance & Evidence