2-Thiophenethiol → HCID 18538833, compound

HRID 412888Notes

Reaction equation

HRID 412888 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11](O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[SH:15][C:16]1[S:17][CH:18]=[CH:19][CH:20]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([S:15][C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 5226742-ThiophenethiolHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 18538833HCID 18538833, compound

Procedure

By a similar manner to Reference Example 35, 1-tert-butoxycarbonyl-4-hydroxypiperidine (1.01 g, 5.0 mmol) was reacted with 2-mercaptothiophene (0.70 g, 6.0 mmol) to give the titled compound as pale yellow oily substance (987 mg, 66%).

Sources & evidence

ORD record
ord-62007ab2ab3b44748f00d416f41abf21
Source dataset
uspto-grants-2003_05
Patent number
US06562978B1

Reaction notes

Loading…