Potassium Iodide → HCID 18538872, compound

HRID 412937Notes

Reaction equation

[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][C:9]1[S:13][C:12]([S:14][CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[N:11][N:10]=1.[C:21]([N:24]1[CH2:29][CH2:28][CH:27]([C:30]([N:32]([C:37]2[CH:42]=[CH:41][CH:40]=[C:39]([Cl:43])[CH:38]=2)[CH2:33][CH2:34][CH2:35]Cl)=[O:31])[CH2:26][CH2:25]1)(=[O:23])[CH3:22].C(=O)([O-])[O-].[K+].[K+].[I-].[K+].[Cl-].[Na+]>C(#N)C>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[C:21]([N:24]1[CH2:29][CH2:28][CH:27]([C:30]([N:32]([C:37]2[CH:42]=[CH:41][CH:40]=[C:39]([Cl:43])[CH:38]=2)[CH2:33][CH2:34][CH2:35][N:18]2[CH2:19][CH2:20][CH:15]([S:14][C:12]3[S:13][C:9]([CH3:8])=[N:10][N:11]=3)[CH2:16][CH2:17]2)=[O:31])[CH2:26][CH2:25]1)(=[O:23])[CH3:22]

Participants

Conditions

Temperature: 80 °C

Procedure

4-(5-Methyl-1,3,4-thiadiazol-2-ylthio)piperidine trifluoroacetate (59 mg, 0.18 mmol) was dissolved in dry acetonitrile (1.5 mL). To the solution were added 1-acetyl-N-(3-chlorophenyl)-N-(3-chloropropyl)-4-piperidinecarboxamide (50 mg, 0.14 mmol), potassium carbonate (77 mg, 0.56 mmol) and potassium iodide (23 mg, 0.14 mmol), and the mixture was stirred at 80° C. for 5 hours. The mixture was cooled to room temperature, and to the mixture was added saturated sodium chloride solution (3 mL). The mixture was extracted three times with ethyl acetate (2 mL). The extracts were combined and concentrated under reduced pressure. The concentrate was purified by using HPLC to give the titled compound as a colorless oily substance (32.2 mg, 28%).

Workup

temperatureThe mixture was cooled to room temperature
extractionThe mixture was extracted three times with ethyl acetate (2 mL)
concentrationconcentrated under reduced pressure
customThe concentrate was purified

Sources & evidence

ORD record: ord-2ebd06ffe6e7402898b28e7a1016bd76
Source dataset: uspto-grants-2003_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06562978B1

Reaction notes

Loading…