Sodium Ascorbate → Mannitol

HRID 412993Notes

Reaction equation

HRID 412993 reaction equation
[O:1]=[C:2]1[O:8][C@H:7]([C@H:9]([CH2:11][OH:12])[OH:10])[C:5]([O-:6])=[C:3]1[OH:4].[Na+].O=C1O[C@H]([C@H](CO)O)C(O)=C1O.[Na].COC(C1C=CC(O)=CC=1)=O.[Na].C(OC(C1C=CC(O)=CC=1)=O)CC>O>[CH2:11]([OH:12])[C@H:9]([C@H:7]([C@@H:5]([C@@H:3]([CH2:2][OH:1])[OH:4])[OH:6])[OH:8])[OH:10]

Participants

6

Reactant 4

HCID 23667548Sodium AscorbateHCID 5324952135285-69-9HCID 54670067L-Ascorbic AcidHCID 665884945026-62-0

Product 1

HCID 6251Mannitol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Procedure

A formulation with 1.5% of the freeze-dried NOE powder from Example 1, 0.05% sodium ascorbate and 0.02% ascorbic acid as antioxidants, 0.1% methylparaben sodium and 0.01% propylparaben sodium as preservatives (Table 5) was prepared under aseptic conditions following the method given in Example 2A. A 2000 mL glass cylinder was weighed and tarred, and the following ingredients (Table 5) except water were weighed and added directly into the glass cylinder. Type I water was added to the mixture and the volume of the mixture was adjusted to 1000 mL. The pH of the solution was approximately 6.49. The freeze-dried powder in 10 mL vials with the ingredients in Table 5 was reconstituted with 10 mL sterile water forming a clear solution within a minute.

Workup

  1. additionadded directly into the glass cylinder

Sources & evidence

ORD record
ord-b6ed17bcae9a4d5baa9413134457cc64
Source dataset
uspto-grants-2003_05
Patent number
US06565897B2

Reaction notes

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