HRID413097

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID79341

Piperidin-4-ol

C5H11NO

结构：CCCc1nc(CC)c2c(=O)[nH]c(-c3cc(S(=O)(=O)Cl)ccc3OCC)nn12

HCID135856749

未命名化合物

结构：CCCc1ncc2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCC(O)CC4)ccc3OCC)nn12

HCID136029276

未命名化合物

PRODUCTS

生成物

结构：CCCc1nc(CC)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCC(O)CC4)ccc3OCC)nn12

HCID135856745

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

By the same method, starting with 640 mg (1.5 mmol) of 4-ethoxy-3-(5-ethyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenesulphonyl chloride and 460 mg (45 mmol) of 4-hydroxypiperidine, 485 mg (66%) of 2-[5-(4-hydroxy-piperidine-1-sulphonyl)-2-ethoxyphenyl]-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one are obtained. Rf=0.37 (dichloromethane/methanol=19:1)

WORKUP

后处理

customare obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4774408daa4b49ec838d11575e13dd98
来源数据集: uspto-grants-2003_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06566360B1
来源说明: uspto-grants-2003_05

反应 SMILES

[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:14]1[NH:19][C:18](=[O:20])[C:17]2=[C:21]([CH2:27][CH3:28])[N:22]=[C:23]([CH2:24][CH2:25][CH3:26])[N:16]2[N:15]=1)[CH3:2].[OH:29][CH:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1.OC1CCN(S(C2C=CC(OCC)=C(C3NC(=O)C4=CN=C(CCC)N4N=3)C=2)(=O)=O)CC1>ClCCl.CO>[OH:29][CH:30]1[CH2:35][CH2:34][N:33]([S:10]([C:7]2[CH:8]=[CH:9][C:4]([O:3][CH2:1][CH3:2])=[C:5]([C:14]3[NH:19][C:18](=[O:20])[C:17]4=[C:21]([CH2:27][CH3:28])[N:22]=[C:23]([CH2:24][CH2:25][CH3:26])[N:16]4[N:15]=3)[CH:6]=2)(=[O:12])=[O:11])[CH2:32][CH2:31]1