Piperidin-4-ol → HCID 135856745, compound

HRID 413097Notes

Reaction equation

HRID 413097 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:14]1[NH:19][C:18](=[O:20])[C:17]2=[C:21]([CH2:27][CH3:28])[N:22]=[C:23]([CH2:24][CH2:25][CH3:26])[N:16]2[N:15]=1)[CH3:2].[OH:29][CH:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1.OC1CCN(S(C2C=CC(OCC)=C(C3NC(=O)C4=CN=C(CCC)N4N=3)C=2)(=O)=O)CC1>ClCCl.CO>[OH:29][CH:30]1[CH2:35][CH2:34][N:33]([S:10]([C:7]2[CH:8]=[CH:9][C:4]([O:3][CH2:1][CH3:2])=[C:5]([C:14]3[NH:19][C:18](=[O:20])[C:17]4=[C:21]([CH2:27][CH3:28])[N:22]=[C:23]([CH2:24][CH2:25][CH3:26])[N:16]4[N:15]=3)[CH:6]=2)(=[O:12])=[O:11])[CH2:32][CH2:31]1

Participants

5

Reactant 3

HCID 79341Piperidin-4-olHCID 135856749HCID 135856749, compoundHCID 136029276HCID 136029276, compound

Product 1

HCID 135856745HCID 135856745, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

By the same method, starting with 640 mg (1.5 mmol) of 4-ethoxy-3-(5-ethyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenesulphonyl chloride and 460 mg (45 mmol) of 4-hydroxypiperidine, 485 mg (66%) of 2-[5-(4-hydroxy-piperidine-1-sulphonyl)-2-ethoxyphenyl]-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one are obtained. Rf=0.37 (dichloromethane/methanol=19:1)

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-4774408daa4b49ec838d11575e13dd98
Source dataset
uspto-grants-2003_05
Patent number
US06566360B1

Reaction notes

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