反应详情

To a solution of 20 ml of concentrated nitric acid and 16 ml of concentrated sulfuric acid was added 3.9 g (0.025 mmol) of 2,6-dimethoxy-4-pyrimidinamine. The resulting solution was stirred at ambient temperature and pressure for thirty minutes and was then stirred at 50° for fifteen minutes. The solution was then cooled in an ice bath to ~0° C. The solid was collected by filtration, washed with water and dried in an oven at 60° C. to afford 3.6 g of the title compound, m.p. 178°-179° C.

1. waitpressure for thirty minutes
2. stirringwas then stirred at 50° for fifteen minutes
3. temperatureThe solution was then cooled in an ice bath to ~0° C
4. filtrationThe solid was collected by filtration
5. washwashed with water
6. customdried in an oven at 60° C.