1,1'-Carbonyldiimidazole → HCID 9966600, compound

HRID 413141Notes

Reaction equation

HRID 413141 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=2)=[CH:4][C:3]=1[C:15]([CH:18]1[CH2:20][CH2:19]1)([OH:17])[CH3:16].[C:21](N1C=CN=C1)(N1C=CN=C1)=[O:22]>>[Cl:14][C:10]1[CH:9]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]3[NH:1][C:21](=[O:22])[O:17][C:15]([CH:18]4[CH2:20][CH2:19]4)([CH3:16])[C:3]=3[CH:4]=2)[CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 235096211-(4-Amino-3'-chloro-biphenyl-3-yl)-1-cyclopropyl-ethanol

Product 1

HCID 9966600HCID 9966600, compound

Procedure

The title compound was prepared from 1-(4-amino-3′-chloro-biphenyl-3-yl)-1-cyclopropyl-ethanol and 1,1′carbonyldiimidazole according to Procedure C. Off-white solid: mp 158-159° C.; 1H-NMR (DMSO-d6) δ10.3 (s, 1H), 7.74 (t, 1H, J=1.71 Hz), 7.67-7.57 (m, 3H), 7.47 (t, 1H, J=7.88 Hz), 7.39 (d, 1H, J=8.1 Hz), 6.95 (d, 1H, J=8.12 Hz), 1.7 (s, 3H), 1.45 (m, 1H), 0.48 (m, 2H), 0.28 (m, 2H); MS (APCI) m/z 314 ([M+H]+, 100%); Anal. Calc. For C18H16ClNO2: C, 68.9; H, 5.14; N, 4.46. Found: C, 68.13; H, 5.01; N, 4.36.

Sources & evidence

ORD record
ord-8d85163123374533bbd7cf8079faf165
Source dataset
uspto-grants-2003_05
Patent number
US06566358B2

Reaction notes

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