(4-Amino-3'-chloro-biphenyl-3-yl)-cyclopropyl-methanone → 1-(4-Amino-3'-chloro-biphenyl-3-yl)-1-cyclopropyl-1-propynyl-methanol

HRID 413142Notes

Reaction equation

HRID 413142 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=2)=[CH:4][C:3]=1[C:15]([CH:17]1[CH2:19][CH2:18]1)=[O:16].[C:20]([Mg]Br)#[C:21][CH3:22]>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=2)=[CH:4][C:3]=1[C:15]([CH:17]1[CH2:18][CH2:19]1)([C:20]#[C:21][CH3:22])[OH:16]

Participants

3

Reactant 2

HCID 23509605(4-Amino-3'-chloro-biphenyl-3-yl)-cyclopropyl-methanoneHCID 178419101HCID 178419101, compound

Product 1

HCID 235096341-(4-Amino-3'-chloro-biphenyl-3-yl)-1-cyclopropyl-1-propynyl-methanol

Procedure

1-(4-Amino-3′-chloro-biphenyl-3-yl)-1-cyclopropyl-1-propynyl-methanol was prepared from (4-amino-3′-chloro-biphenyl-3-yl)-cyclopropyl-methanone and propynylmagnesium bromide according to Example 41.

Sources & evidence

ORD record
ord-53847125d2b8483d95ae816528387484
Source dataset
uspto-grants-2003_05
Patent number
US06566358B2

Reaction notes

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