1,1'-Carbonyldiimidazole → HCID 10290991, compound

HRID 413145Notes

Reaction equation

HRID 413145 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=2)=[CH:4][C:3]=1[C:15]([CH:20]1[CH2:22][CH2:21]1)([CH:17]1[CH2:19][CH2:18]1)[OH:16].[C:23](N1C=CN=C1)(N1C=CN=C1)=[O:24]>>[Cl:14][C:10]1[CH:9]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]3[NH:1][C:23](=[O:24])[O:16][C:15]([CH:17]4[CH2:19][CH2:18]4)([CH:20]4[CH2:21][CH2:22]4)[C:3]=3[CH:4]=2)[CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 22736625HCID 22736625, compound

Product 1

HCID 10290991HCID 10290991, compound

Procedure

The title compound was prepared according to Example 41 from (4-amino-3′-chloro-biphenyl-3-yl)-dicylopropyl-methanol and 1,1′-carbonyldiimidazole. Yellow solid: mp 198-200° C.; 1H-NMR (DMSO-d6) δ10.3 (s, 1H), 7.72 (bs, 1H), 7.67 (bs, 1H), 7.62 (m, 2H), 7.48 (t, 1H, J=7.88 Hz), 7.40 (d, 1H, J=8.04 Hz), 6.94 (d, 1H, J=8.27 Hz), 1.55 (m, 2H), 0.5 (m, 6H), 0.28 (m, 2H); MS (EI) m/z 339 (M+, 40%); Anal. Calc. For C20H18ClNO2: C, 70.69; H, 5.34 N, 4.12. Found: C, 69.38; H, 5.07; N, 4.02.

Sources & evidence

ORD record
ord-d513364b82b74a4b8b3df74f17bfe8e7
Source dataset
uspto-grants-2003_05
Patent number
US06566358B2

Reaction notes

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