Trifluoroacetic acid → HCID 44303837, compound

HRID 413225Notes

Reaction equation

HRID 413225 reaction equation
C([O:5][C:6](=[O:42])[C@@H:7]([NH:28][S:29]([C:32]1[CH:37]=[CH:36][C:35]([C:38]([F:41])([F:40])[F:39])=[CH:34][CH:33]=1)(=[O:31])=[O:30])[CH2:8][NH:9][C:10]([C:12]1[S:13][C:14]([CH2:17][CH2:18][C:19](=[O:27])[NH:20][C:21]2[NH:22][CH2:23][CH2:24][CH2:25][N:26]=2)=[CH:15][CH:16]=1)=[O:11])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH:22]1[CH2:23][CH2:24][CH2:25][N:26]=[C:21]1[NH:20][C:19]([CH2:18][CH2:17][C:14]1[S:13][C:12]([C:10]([NH:9][CH2:8][C@H:7]([NH:28][S:29]([C:32]2[CH:33]=[CH:34][C:35]([C:38]([F:40])([F:41])[F:39])=[CH:36][CH:37]=2)(=[O:30])=[O:31])[C:6]([OH:42])=[O:5])=[O:11])=[CH:16][CH:15]=1)=[O:27]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69637294HCID 69637294, compound

Product 1

HCID 44303837HCID 44303837, compoundYield 868.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.096 g (0.15 mmol) of the compound obtained in step b) were dissolved in dichloromethane (1 ml). Trifluoroacetic acid (1 ml) was added and the reaction mixture was stirred for 3 h at room temperature. After evaporation of the solvents lyophilization gave the title compound (0.75 g, 86%) as a white amorphous solid.

Workup

  1. customAfter evaporation of the solvents lyophilization

Sources & evidence

ORD record
ord-7f99f953a5224f49a038dd3db6ecbc43
Source dataset
uspto-grants-2003_05
Patent number
US06566366B1

Reaction notes

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