Trifluoroacetic acid → HCID 44303611, compound

HRID 413227Notes

Reaction equation

HRID 413227 reaction equation
C([O:5][C:6](=[O:42])[C@@H:7]([NH:28][S:29]([C:32]1[CH:37]=[CH:36][C:35]([C:38]([CH3:41])([CH3:40])[CH3:39])=[CH:34][CH:33]=1)(=[O:31])=[O:30])[CH2:8][NH:9][C:10]([C:12]1[S:13][C:14]([CH2:17][CH2:18][C:19](=[O:27])[NH:20][C:21]2[NH:22][CH2:23][CH2:24][CH2:25][N:26]=2)=[CH:15][CH:16]=1)=[O:11])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[C:38]([C:35]1[CH:34]=[CH:33][C:32]([S:29]([NH:28][C@@H:7]([CH2:8][NH:9][C:10]([C:12]2[S:13][C:14]([CH2:17][CH2:18][C:19](=[O:27])[NH:20][C:21]3[NH:22][CH2:23][CH2:24][CH2:25][N:26]=3)=[CH:15][CH:16]=2)=[O:11])[C:6]([OH:42])=[O:5])(=[O:31])=[O:30])=[CH:37][CH:36]=1)([CH3:41])([CH3:39])[CH3:40]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69637249HCID 69637249, compound

Product 1

HCID 44303611HCID 44303611, compoundYield 103.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.27 g (0.43 mmol) of the compound obtained in step b) were dissolved in dichloromethane (1 ml). Trifluoroacetic acid (1 ml) was added and the reaction mixture was stirred for 2 h at room temperature. After evaporation of the solvents lyophilization gave the title compound (0.25 g, 86%) as a white amorphous solid.

Workup

  1. customAfter evaporation of the solvents lyophilization

Sources & evidence

ORD record
ord-8373e821c25f4324ad2b913ed7f802f9
Source dataset
uspto-grants-2003_05
Patent number
US06566366B1

Reaction notes

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