反应详情

Reflux 5-trifluoromethyl-1,3-dihydro-benzimidazol-2-one (17 g; Meanwell et al. (1995) J. Org. Chem. 60(6):1565-1582) for 14 hours in POCl3 (200 mL). Evaporate the solvent in vacuo, then carefully neutralize with saturated NaHCO3, and extract with EtOAc. Dry over Na2SO4, concentrate under vacuum, and purify by flash chromatography (1 :1 hexanes/EtOAc) to obtain 2-chloro-5-trifluoromethyl-1H-benzimidazole.

1. customEvaporate the solvent in vacuo
2. extractionextract with EtOAc
3. dry with materialDry over Na2SO4
4. concentrationconcentrate under vacuum
5. custompurify by flash chromatography (1 :1 hexanes/EtOAc)