Potassium Carbonate → HCID 69491289, compound

HRID 413272Notes

Reaction equation

HRID 413272 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11]Br)=[CH:2]1.[NH:13]1[CH2:18][CH2:17][CH:16]([NH:19][C:20](=[O:26])[O:21][C:22]([CH3:25])([CH3:24])[CH3:23])[CH2:15][CH2:14]1.C(=O)([O-])[O-].[K+].[K+].S([O-])([O-])(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC>O.C1(C)C=CC=CC=1>[C:22]([O:21][C:20]([NH:19][CH:16]1[CH2:15][CH2:14][N:13]([CH2:11][CH2:10][C:3]2[C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=3[O:1][CH:2]=2)[CH2:18][CH2:17]1)=[O:26])([CH3:25])([CH3:23])[CH3:24]

Participants

7

Reactant 4

HCID 11430Potassium CarbonateHCID 7238334-(N-Boc-amino)piperidineHCID 11433187Bis(tetrabutylammonium) sulphateHCID 150754803-(2-bromoethyl)Benzofuran

Product 1

HCID 69491289HCID 69491289, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1140TolueneSolvent

Procedure

10 mmol of 2-(benzofuran-3-yl)-1-bromoethane, 9.62 mmol of tert-butyl 4-piperidyl-carbamate, 2.65 g of potassium carbonate and 0.65 g of tetrabutylammonium sulphate are added to 10 ml of toluene. After refluxing for 12 hours, the mixture is taken up in water. The organic phase is then washed with water, dried and then filtered. Evaporation under reduced pressure allows the expected product to be isolated.

Workup

  1. temperatureAfter refluxing for 12 hours
  2. washThe organic phase is then washed with water
  3. customdried
  4. filtrationfiltered
  5. customEvaporation under reduced pressure
  6. customto be isolated

Sources & evidence

ORD record
ord-63216064a60b435e94628974fcca567b
Source dataset
uspto-grants-2003_05
Patent number
US06566364B2

Reaction notes

Loading…