反应详情

To a solution of 12 (300 mg, 1.12 mmol) in THF was added 1.24 mL of a 1.8M nBu2O solution of phenyl lithium at −40° C. After stirring for 15 min, the reaction was quenched with water (1 mL). MgSO4 was added and the mixture filtered to give a yellow solution. Removal of the solvent under vacuum gave C1 as a yellow oil (240 mg, 62% yield).

1. customthe reaction was quenched with water (1 mL)
2. additionMgSO4 was added
3. filtrationthe mixture filtered
4. customto give a yellow solution
5. customRemoval of the solvent under vacuum