2-Methylphenyl boronic acid → HCID 22279314, compound

HRID 413320Notes

Reaction equation

HRID 413320 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15](F)[CH:14]=3)[CH:11]=2)[NH:6][C:5](=[O:20])[CH:4]=1.[CH3:23]C1C=CC=CC=1B(O)O>>[F:1][C:2]([F:22])([F:21])[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH3:23])[CH:11]=2)[NH:6][C:5](=[O:20])[CH:4]=1

Participants

3

Reactant 2

HCID 27332672-Methylphenyl boronic acidHCID 22279276HCID 22279276, compound

Product 1

HCID 22279314HCID 22279314, compound

Procedure

This compound was made according to General Procedure XXIV in Example 406 from Compound 308 (Structure 16c of Scheme XXX, where R=H, R1=trilfuoromethyl) and commercially available 2-methylbenzeneboronic acid. Compound 742 was isolated as a white solid: 1H NMR (400 MHz, DMSO-d6) 12.42 (s, 1H), 7.68 (dd, J=9.6, 1.4, 1H), 7.53 (m, 2H), 7.33-7.23 (m, 4H), 7.04 (s, 1H), 2.51 (s, 3H).

Sources & evidence

ORD record
ord-6070634a01cb4732b06c55196cdaf497
Source dataset
uspto-grants-2003_05
Patent number
US06566372B1

Reaction notes

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