4-Bromobiphenyl → 4-BROMO-4'-SULFOBIPHENYL

HRID 413362Notes

Reaction equation

HRID 413362 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl[S:15]([OH:18])(=[O:17])=[O:16]>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:15]([OH:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 71014-BromobiphenylHCID 24638Chlorosulfonic acid

Product 1

HCID 45247074-BROMO-4'-SULFOBIPHENYL

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 4-bromobiphenyl (18.6 g, 79.8 mmol) in chloroform (150 mL) is added dropwise chlorosulfonic acid (11.2 g, 96 mmol). A white solid precipitate forms during the addition. The reaction is stirred at room temperature for 6 hr, at which time the precipitate is collected by filtration and the precipitate is then washed with cold chloroform. The product is dried under vacuum to give a white solid product. The product is used without further purification.

Workup

  1. additionA white solid precipitate forms during the addition
  2. filtrationis collected by filtration
  3. washthe precipitate is then washed with cold chloroform
  4. customThe product is dried under vacuum
  5. customto give a white solid product
  6. customThe product is used without further purification

Sources & evidence

ORD record
ord-2c490a80a7fe4849aebeb78957365799
Source dataset
uspto-grants-2003_05
Patent number
US06566381B1

Reaction notes

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