huagongshe.com
HRID413466

反应详情

EQUATION

反应方程式

HRID 413466 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)C2CC[C@@]1(CS(=O)(=O)O)C(=O)C2
HCID218580

未命名化合物

结构：O=C1[C@H]2NCCC[C@H]2C(=O)N1Cc1ccccc1
HCID7472044

(4aR,7aS)-Tetrahydro-6-(phenylmethyl)-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione

C14H16N2O2

PRODUCTS

生成物

1
结构：CC1(C)C2CC[C@@]1(CS(=O)(=O)O)C(=O)C2.O=C1[C@H]2CCCN[C@H]2C(=O)N1Cc1ccccc1
HCID86758982

未命名化合物

收率 42%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

0.53 g (2.18 mmol) of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane (racemate) and 0.51 g (2.18 mmol) of (1S)-camphorsulfonic acid are dissolved in 30 ml of acetone under reflux to give a clear solution and cooled to room temperature. The precipitated solid is filtered off with suction and dried in vacuo to give 0.23 g (0.49 mmol) of (1R,6S)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane-(1S)-camphorsulfonic acid salt.

WORKUP

后处理

  1. temperatureunder reflux
  2. customto give a clear solution
  3. filtrationThe precipitated solid is filtered off with suction
  4. customdried in vacuo