(1S)-(+)-Camphor-10-sulphonic acid → (1r,6s)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane-(1S)-camphorsulfonic acid salt

Participants

Reaction Steps

0.53 g (2.18 mmol) of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane (racemate) and 0.51 g (2.18 mmol) of (1S)-camphorsulfonic acid are dissolved in 30 ml of acetone under reflux to give a clear solution and cooled to room temperature. The precipitated solid is filtered off with suction and dried in vacuo to give 0.23 g (0.49 mmol) of (1R,6S)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane-(1S)-camphorsulfonic acid salt.

Provenance & Evidence