反应详情

A suspension of 10 g of iminostilbene in 100 ml toluene was treated with 20.2 g of sodium cyanate and 27.5 g of mandelic acid and was heated to reflux for about 10 hrs. The reaction mixture was cooled to room temperature and charged with sodium hydroxide solution and maintained for 8 hrs. The resulting suspension was filtered, washed with water and dried to give 11 g of carbamazepine.

1. temperaturewas heated
2. temperatureto reflux for about 10 hrs
3. temperaturemaintained for 8 hrs
4. filtrationThe resulting suspension was filtered
5. washwashed with water
6. customdried