Methyl[2-(pyridin-4-yl)ethyl]amine → (2E)-5-Amino-5-methylhex-2-enoic acid N-methyl-N-[(1R)-1-(N-methyl-N-{(1R)1-[N-methyl-(2-(4-pyridinyl)ethyl)carbamoyl]-2-phenylethyl}carbamoyl)-2-(2-naphthyl)ethyl]amide

Participants

Role	Name	HCID	Charge
Reactant	Methyl[2-(pyridin-4-yl)ethyl]amine	HCID 143276	—
Reactant	N-Boc-N-methyl-D-phenylalanine	HCID 7015127	—
Reactant	(2R)-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]-3-naphthalen-2-ylpropanoic acid	HCID 10065151	—
Reactant	(2E)-5-(tert-Butyloxycarbonylamino)-5-methylhex-2-enoic acid	HCID 10847814	—
Product	(2E)-5-Amino-5-methylhex-2-enoic acid N-methyl-N-[(1R)-1-(N-methyl-N-{(1R)1-[N-methyl-(2-(4-pyridinyl)ethyl)carbamoyl]-2-phenylethyl}carbamoyl)-2-(2-naphthyl)ethyl]amide	HCID 9852273	—

Reaction Steps

The title compound was prepared as in example 1 (except from step 3, see below) using 4-[2-(Methylamino)ethyl]pyridin, (2R)-2-(N-(tert-Butoxycarbonyl)-N-methylamino)-3-phenylpropionic acid, (2R)-2-(N-(tert-butoxycarbonyl)-N-methylamino)-3-(2-naphthyl)propionic acid and (2E)-5-(tert-Butoxycarbonylamino)-5-methylhex-2-enoic acid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06566337B1
Source dataset	uspto-grants-2003_05
ORD ID	ord-e04ed25e12124a03b0a525cd351bb744
Source note	uspto-grants-2003_05