Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethylamine | HCID 1146 | — |
| Reactant | 4-Chloro-3-hydroxybutyric acid ethyl ester, (3R)- | HCID 2734445 | — |
| Solvent | Water | HCID 962 | — |
| Product | (-)-Carnitine | HCID 10917 | 75% |
Reaction Steps
400 g of crude ethyl (+) (R)-4-chloro-3-hydroxybutyrate, prepared according to Example 8, and 1 l of 45% trimethylamine in H2O are placed in a 2-liter reactor. The reaction mixture is heated to 80° C. and kept at this temperature for 15 h. After cooling and removing the excess of trimethylamine under nitrogen flow, the aqueous solution is extracted with 1.9 l of methylene chloride and analyzed with HPLC. L-carnitine is obtained with 75% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06566552B2 |
|---|
| Source dataset | uspto-grants-2003_05 |
|---|
| ORD ID | ord-c8f4026d15844e13a4a08c4f23aeab51 |
|---|
| Source note | uspto-grants-2003_05 |
|---|
