反应详情

温度

80 °C

110 g of ethyl (+) (R)-4-chloro-3-hydroxybutyrate, prepared according to Example 2, and 280 ml of 45% trimethylamine in H2O are placed in a 0.6-liter reactor. The reaction mixture is heated to 80° C. and kept at this temperature for 2 h. After cooling and removing the excess of trimethylamine, the aqueous solution is extracted with 0.5 l of methylene chloride and analyzed with HPLC. L-carnitine is obtained with 71% yield.

1. customare placed in a 0.6-liter reactor
2. temperatureAfter cooling
3. customremoving the excess of trimethylamine
4. extractionthe aqueous solution is extracted with 0.5 l of methylene chloride