反应详情

温度

3 °C

suspended anhydrous AlCl3 (156 g, 1.15 mol) in toluene (1500 mL) and cool to 2-4° C. Add, by slow addition, a solution of 4-chlorobutyryl chloride (165.5 g, 1.15 mol) in toluene (300 mL). Stir for 15 minutes and pour into stirring ice-water (2.5L). Stir for 30 hours, decant the toluene and extract the aqueous phase with toluene (700 mL). Combine the organic layers and wash three times with water (1L, 1L. 500 mL). Evaporate the solvent in vacuo to give the title compound as a pale yellow oil (292.3 g, 95%).

1. additionAdd, by slow addition
2. additionpour
3. stirringStir for 30 hours
4. customdecant the toluene
5. extractionextract the aqueous phase with toluene (700 mL)
6. washCombine the organic layers and wash three times with water (1L, 1L. 500 mL)
7. customEvaporate the solvent in vacuo