HCID 54008227, compound → HCID 9817918, compound

HRID 413618Notes

Reaction equation

HRID 413618 reaction equation
C([O:8][C:9](=[O:38])[CH:10]([NH:27]C(OCC1C=CC=CC=1)=O)[CH2:11][O:12][C:13]([O:15][CH:16]([CH3:26])[CH2:17][CH2:18][CH2:19][CH:20]([CH3:25])[CH2:21][CH:22]([CH3:24])[CH3:23])=[O:14])C1C=CC=CC=1>[Pd].CO>[NH2:27][CH:10]([CH2:11][O:12][C:13]([O:15][CH:16]([CH3:26])[CH2:17][CH2:18][CH2:19][CH:20]([CH3:25])[CH2:21][CH:22]([CH3:24])[CH3:23])=[O:14])[C:9]([OH:38])=[O:8]

Participants

4

Reactant 1

HCID 54008227HCID 54008227, compound

Product 1

HCID 9817918HCID 9817918, compoundYield 97.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 4.81 g 2-benzyloxycarbonylamino-3-(1,5,7-trimethyl-octyloxycarbonyloxy)-propionic acid benzyl ester, 250 ml methanol and a catalytic amount of 10% Pd/C was stirred six hours under an atmosphere of hydrogen. Filtration over Celite and evaporation under reduced pressure gave 2.69 g of colorless crystals.

Workup

  1. filtrationFiltration
  2. customover Celite and evaporation under reduced pressure

Sources & evidence

ORD record
ord-74939db1f0bc486f945694f26ede0895
Source dataset
uspto-grants-2003_05
Patent number
US06569411B2

Reaction notes

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