Glutaric anhydride → HCID 18521562, compound

HRID 413710Notes

Reaction equation

HRID 413710 reaction equation
[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2]1.[CH3:9][O:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>O1CCOCC1>[CH3:9][O:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][N:16]([C:5](=[O:6])[CH2:4][CH2:3][CH2:2][C:1]([OH:7])=[O:8])[CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 7940Glutaric anhydride2×HCID 27346381-(2-Methoxyethyl)piperazine

Product 1

HCID 18521562HCID 18521562, compoundYield 98.9%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

1.52 g of glutaric anhydride and then 1.92 g of 1-(2-methoxyethyl)piperazine in solution in 3 cm3 of dioxane are added to 13 cm3 of dioxane. After stirring for 5 hours at room temperature, an additional 300 mg of glutaric anhydride are added and then the stirring is continued at 20° C. for 18 hours. The solvent is evaporated under reduced pressure and the resulting oil is dried at 20° C. (90 Pa) to give 3.4 g of 5-[4-(2-methoxyethyl)piperazin-1-yl]-5-oxopentanoic acid in the form of an orange-colored lacquer which is used as it is.

Workup

  1. waitthe stirring is continued at 20° C. for 18 hours
  2. customThe solvent is evaporated under reduced pressure
  3. customthe resulting oil is dried at 20° C. (90 Pa)

Sources & evidence

ORD record
ord-fe61a0bbe27941fe8091f0eb4900f999
Source dataset
uspto-grants-2003_05
Patent number
US06569854B1

Reaction notes

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