1-Methylpiperazine → HCID 16469298, compound

HRID 413713Notes

Reaction equation

HRID 413713 reaction equation
[CH3:1][CH:2]1[CH2:8][C:7](=[O:9])[O:6][C:4](=[O:5])[CH2:3]1.[CH3:10][N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>O1CCOCC1>[CH3:1][CH:2]([CH2:3][C:4]([N:14]1[CH2:15][CH2:16][N:11]([CH3:10])[CH2:12][CH2:13]1)=[O:5])[CH2:8][C:7]([OH:6])=[O:9]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 778283-Methylglutaric anhydride2×

Product 1

HCID 16469298HCID 16469298, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1.6 g of 3-methylglutaric anhydride and then 1.48 cm3 of N-methylpiperazine are added to 20 cm3 of dioxane. After stirring for 4 hours, an additional 320 mg of 3-methylglutaric anhydride are added. The stirring is continued at 20° C. for 18 hours. The solvent is evaporated under reduced pressure (2.7 kPa), at 50° C. The resulting oil is dried at 50° C. (90 Pa) to give 3.1 g of (3RS)-3-methyl-5-(4-methylpiperazin-1-yl)-5-oxopentanoic acid in the form of a yellow lacquer which is used as it is.

Workup

  1. waitThe stirring is continued at 20° C. for 18 hours
  2. customThe solvent is evaporated under reduced pressure (2.7 kPa), at 50° C
  3. customThe resulting oil is dried at 50° C. (90 Pa)

Sources & evidence

ORD record
ord-4de4891661f644958cf211a2d23de78d
Source dataset
uspto-grants-2003_05
Patent number
US06569854B1

Reaction notes

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