Hydrochloric Acid → HCID 18522077, compound

HRID 413741Notes

Reaction equation

HRID 413741 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([NH:13]C(=O)C)=[CH:9][CH:8]=2)[C:5]2[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=2[N:3]=1.[ClH:21]>>[ClH:21].[NH2:1][C:2]1[N:6]([C:7]2[CH:8]=[CH:9][C:10]([NH2:13])=[CH:11][CH:12]=2)[C:5]2[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18522088HCID 18522088, compound

Product 1

HCID 18522077HCID 18522077, compound

Procedure

2-Amino-1-(4-acetamidophenyl)benzimidazole (1.78 g, 6.68 mmol) was refluxed in hydrochloric acid (25 ml) overnight. The crude mixture was evaporated and triturated with diethyl ether. Yield 1.68 g, 96%, M.p. 258-260° C.

Workup

  1. customThe crude mixture was evaporated
  2. customtriturated with diethyl ether

Sources & evidence

ORD record
ord-92b55c1fe30c41e88f4577a341971e5b
Source dataset
uspto-grants-2003_05
Patent number
US06569880B2

Reaction notes

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