反应详情

温度

150 °C

A mixture of 2-amino-4-phenylthiazole (12.5 g, 80.9 mmol), 1-fluoro-2-nitrobenzene (12.5 g, 89.0 mmol), potassium carbonate (13.4 g, 97.1 mmol) was stirred at 150° C. for 24 h. Water (100 ml) was added and the mixture was extracted twice with 1,2-dichloroethane (50 ml). The crude extract was purified by chromatography on silica gel using toluene as eluent. The product was isolated as the free base. Yield 7.95 g, 33%. M.p. 114-116° C.

1. extractionthe mixture was extracted twice with 1,2-dichloroethane (50 ml)
2. extractionThe crude extract
3. customwas purified by chromatography on silica gel
4. customThe product was isolated as the free base